What are the Side Effects of the Depo Shot?

August 29, 2025

Share this Article:

Finding the right birth control method can feel overwhelming, especially if you're sorting through a lot of options and opinions. If you're considering the Depo shot or already using it, you might be wondering how it could affect your body. Understanding what to expect can help you feel more confident and informed as you think through your next steps.

What is the Depo Shot?

The Depo shot, also called Depo-Provera, is a birth control injection that contains a hormone called progestin. It’s given once every three months, usually in the arm or hip, and is designed to help prevent pregnancy during that time.


Some women choose the Depo shot because it doesn’t require daily pills or frequent appointments. It’s a long-acting method that can offer privacy and convenience, especially for those who prefer not to use other forms of contraception.

Forms of birth control: the pill and the Depo shot.

How Does the Depo Shot Work?

The Depo shot works mainly by stopping ovulation. Without ovulation, there’s no egg released for sperm to fertilize. It also thickens cervical mucus, which makes it harder for sperm to reach an egg. At the same time, it thins the lining of the uterus, making it less likely for a fertilized egg to attach.


Once the shot is given, it starts working quickly. If taken during the first five days of a menstrual cycle, it typically begins to prevent pregnancy within 24 hours. Each dose stays active in the body for about 12 to 13 weeks.

Is the Depo Shot Safe?

Many women choose injectable birth control because it’s simple and long-lasting. The Depo shot is FDA-approved and has been widely used as a reliable option for pregnancy prevention.


Still, it’s not the right fit for everyone. Some women experience side effects, and there are certain health conditions where this method may not be recommended. These include unexplained vaginal bleeding or a history of bone loss. Studies have also shown that using the shot for more than two years may lead to a drop in bone density, which can increase the risk of fractures over time.


Before deciding, it’s helpful to talk with a provider who can review your personal health history and explain what to watch for.

What Are the Side Effects of the Depo Shot?

Like any form of hormonal birth control, the Depo shot can cause side effects. Some are short-term and may go away after a few weeks or months. Others can last as long as you're using the method.


Common side effects include:


  • Irregular bleeding or spotting
  • Lighter or missed periods
  • Headaches
  • Weight gain
  • Mood changes
  • Breast tenderness
  • Lower sex drive


Some women may also notice a delay in the return of their regular cycle after stopping the shot. It can take several months, and in some cases up to a year, for fertility to return.


While not everyone will experience problems, it's important to be aware of what could happen so you’re not caught off guard. If anything feels off or uncomfortable, checking in with a medical provider is always a good idea.

Thinking About Your Birth Control Options?

Choosing birth control is personal, and it’s okay to have questions. If you're trying to figure out what’s right for your body or feel unsure about the side effects of the Depo shot, you’re not alone.


Willow Womens Center offers a
calm, pressure-free place to talk through your options. If you're facing an unplanned pregnancy or need STI testing, our team is here to support you with care that respects your choices.


Schedule a no-cost consultation today. We’re here to help you get clarity, not judgment.

Connect with Us:

Pregnant woman representing successful conception during the fertile window.
August 20, 2025
Learn what a fertile window is, the best day in the fertile window to conceive, and how Willow Womens Center can help.
A pregnant woman at her first prenatal visit.
August 7, 2025
Learn key questions to ask at your first prenatal visit to feel confident, informed, and prepared for what’s ahead.
A woman is holding a pill in her hand.
By Willow Womens June 17, 2025
Learn how the abortion pill works, its risks, and safety considerations. Get medically accurate info and confidential support from Willow Womens Center.
A nurse is talking on a headset while sitting in front of a computer.
May 22, 2025
Get expert answers anytime with our Pregnancy 24/7 Nurse Chat—support, guidance, and peace of mind whenever you need it.
A woman is sitting on a couch holding her stomach in pain.
March 21, 2025
A pregnancy test can confirm pregnancy by detecting hCG levels, but it cannot diagnose an ectopic pregnancy. If you have severe pain or abnormal bleeding, seek medical attention immediately.
A woman is laying on a bed with a baby wrapped in a blanket.
March 20, 2025
Learn about maternity leave rights in Wisconsin, including eligibility, FMLA coverage, state laws, and employer policies to help you plan for time off.
A woman is holding a pregnancy test in her hands.
March 13, 2025
Yes, pregnancy tests do expire! Learn how expiration affects accuracy, how to store tests properly, and when to trust your results for the most reliable outcome.
A man is hugging a pregnant woman 's belly in a black and white photo.
December 19, 2024
Prepare for fatherhood with these essential tips for first-time dads. From emotional readiness to practical advice, get ready for the journey ahead!
A woman is sitting on a couch talking to a doctor.
November 26, 2024
Explore the ways STIs and STDs can be transmitted without sexual contact, including through shared needles, childbirth, or contaminated objects.
A pregnant woman is sitting on a bed holding a baby.
November 25, 2024
Learn practical tips for preparing for motherhood as a single mom, from financial planning to building a support system and prioritizing self-care.